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Originally published Saturday, December 7, 2013 at 8:06 PM

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Keys to the game

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Corralling Colin?

Colin Kaepernick has had two of his poorer performances against Seattle, going 32 for 64 for 371 yards with one touchdown and four interceptions in games won by Seattle by a combined 71-16. But each of those games were in the comfy confines of CenturyLink Field. He also didn’t have his full complement of receivers in the Week 2 game in Seattle. He does now, and he’ll be at home, surely hoping for some redemption.

The battle in the trenches

Always a key, it might be more so in a game like this that figures to be physical, emotional and intense. The edge could go to Seattle’s defensive line with San Francisco nursing injuries on its offensive line. Specifically, left tackle Joe Staley is questionable with a knee injury and left guard Mike Iupati is ailing with a knee injury. Right guard Alex Boone will move to left tackle if Staley can’t go. The Seahawks’ offensive line, meanwhile, will be back to full strength for a third straight game. Still, the Seahawks will need to get the running attack going better than the past two games, when Seattle has averaged just 3.3 yards per carry.

Sherman and Boldin

San Francisco receiver Anquan Boldin leads the 49ers with 61 receptions for 822 yards. But he was held to just one catch for 7 yards in the first game against the Seahawks after Seattle decided to use cornerback Richard Sherman as his primary defender. It was an out-of-character move for the Seahawks, who usually just leave Sherman on the left side. With Michael Crabtree back, the Seahawks might not be able to single out Boldin as much as the first game.

Bob Condotta

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